IGF-1 Long R3
SHORT IGF-1 LONG R3 DESCRIPTION:
IGF-1 stimulates the growth of nearly all tissues. This includes not just skeletal muscle, but almost all organs in the body barring, the brain and eyes. Being that muscle tissue is meant to respond to external stress stimulus with rapid changes in size and strength, it is much more responsive to IGF-1 therapy than other internal organs. Dosage for IGF-1 is around 30 mcg per day for the recreational bodybuilder, which allows a 1 mg vial to last for about a month. Cycle length is usually limited to somewhere between 4 and 12 weeks. After this point a break of at least 4-6 weeks is usually taken, to ensure maximum responsiveness when drug therapy is again initiated. There are other potentially serious side effects to IGF-1 therapy that need to be considered. These mimic the risks associated with GH therapy very closely, and include pronounced internal organ growth, thickening of the bones and skin (GH jaw), Insulin resistance, hypoglycemia, water retention and edema, and even gynecomastia in very sensitive users. Some people also report carpel tunnel syndrome from the overuse of GH or IGF-1, which may be preceded by numbness or discomfort in the hands and wrists. GH is known to be a strong drug, and IGF-1 is its powerful big brother in almost all regards.
LONG IGF-1 LONG R3 DESCRIPTION:
Insulin-Like Growth Factor-1, of which IGF-1 Long R3 of is derived, is a peptide hormone found naturally in the human body. It belongs to the same family of hormones as Insulin. As peptide hormones go, IGF-1 is relatively small, containing only 70 amino acids. That, however, bears no relevance to how important this hormone is biologically. IGF-1 is the mediator of all of the anabolic activity of growth hormone which, in of itself, is not anabolic at all. It is the ability of Growth Hormone to stimulate the release of IGF-1 that makes this drug an effective muscle-building agent. The IGF-1 hormone was discovered back in 1957. At first it was believed to exert its main functions of the growth of cartilage. It was not until the late 1970’s that the name IGF-1 was finally adopted, and a more detailed understanding of its full properties began to develop. The recent introduction of recombinant human IGF-1 for clinical study (and its potential as an actual therapeutic drug) has opened new doors into the exploration of this powerful anabolic hormone.
IGF-1 stimulates the growth of nearly all tissues. This includes not just skeletal muscle, but almost all organs in the body barring, the brain and eyes. Being that muscle tissue is meant to respond to external stress stimulus with rapid changes in size and strength, it is much more responsive to IGF-1 therapy than other internal organs. Even though info exerts a “whole body” anabolic effect, it is not so pronounced that the drug cannot be used safely to support skeletal muscle growth (one must never ignore the possibility of organ enlargement, however). Early drug trials with both animals and humans have been promising thus far, and recombinant human IGF-1 has already been approved in the offer growth deficiency in children. We can be optimistic that the next decade will bring a number of new clinical investigations, perhaps looking at many potential uses of IGF-1 in adults including: a lean mass preservative for patients suffering from HIV and AIDS, an anabolic for patients suffering from cancer or other debilitating conditions, as a general recovery aid for burn victims, and even for replacement of lowering IGF-1 levels with age.
The anabolic effect of IGF-1 toward skeletal muscle tissue is characterized by increases in satellite cell activity, muscle DNA content, and muscle protein content. It is believed to enhance the incorporation of new satellite cells into muscle fibers mainly through a reduction in the output of the growth inhibitor “p27Kip1”. We further understand that both GH and IGF-1 therapy coincide with suppressed levels of Myostatinz, a powerful growth-regulating (limiting) hormone. GH and IGF-1 are both powerful anabolic drugs, which exert their actions on muscle tissue in ways different from classic anabolic steroids. They are looked upon more so as drugs that stimulate hyperplasia, or increases in cell number (although admittedly these drugs trigger both hyperplasia and hypertrophy). There is no question that IGF-1 increases muscle size via a valid growth effect. not the increases in cell volume due to swelling that were suggested in earlier liver studiesz. The main question now is, how strong is this effect? As this drug leaves the medical books and enters real world application, this question is being answered fairly quickly.
There were initially some issues with potentially using IGF-1 as a therapeutic drug that needed to be overcome. The main problem is its rate of metabolic clearance, which is so rapid that twice-daily injections are needed with rhIGF-1 for effective blood levels to be sustained. It is the same early issue scientists noticed with Testosterone, except magnified many times over, as free Testosterone actually lasts far longer in the blood than IGF-1. Scientists were forced to search out ways to maximize the half-life of the drug before it could be used therapeutically. By the late 1990’s, much progress had been made. Several ways involved synthetically modifying the hormone. One extremely popular variant in the research has been this one, which carries an arginine at residue 3 and an N-terminal extension. It has been named LR3-IGF-1 or “IGF-1 Long R3” due to the lengthening at the 3rd residue position. It has a longer half-life than Insulin, and is resistant to binding proteins, such that the drug is highly active next to endogenous IGF-1. IGF-1 Long R3 has been shown in studies to be 2.5-3 times more potent than regular IGF-1 in restoring growth.
IGF-1 Long R3 is currently being manufactured by GroPep in Australia, which hold patent on this unique synthetic form of IGF-1. As a potential therapeutic drug, it is officially in the experimental stages of development. Some bodybuilders have been able to obtain it “for research projects” through international distributors who sell to Universities and biotechnology companies. It usually costs around $175-400 per milligram, for a standard “media” grade form of the drug. This is said to be >85% purity, and has been working fine for bodybuilding purposes. It is also sold as a “receptor grade” material, which exceeds 99% purity. This material is used for the most sensitive studies, and has come to be looked at as the choice form of IGF-1 for the discriminating bodybuilder (it is pharmaceutical quality). It can be located at a reasonable price (somewhat close to media grade) when purchased in bulk; otherwise it can be exceedingly expensive (over $700 per milligram).
Both grades of research material usually come as plain lyophilized powder, or suspended in a solvent like benzyl alcohol. If you have the former, it is typically mixed with benzyl alcohol for storage, and diluted with sterile saline or bacteriostasis water for use. When obtained in benzyl alcohol, the user would typically draw a tiny amount (the immediate dosage) into an Insulin syringe, and dilute it before injection by drawing in extra bacteriostasis water. All unused portions of the drug should be refrigerated.
IGF-1 Long R3 is also sold under the brand name IGtropin, produced by the Chinese manufacturer GenSci (the makers of JinTropin rHGH). This is supposed to be the same exact compound supplied by GroPep however, it is uncertain at this time if they obtain the material through any agreements with the company. Feedback on the product has been very good thus far, suggesting that whatever the source, they are indeed supplying real IGF-1 Long R3. The GenSci product is a little bit more expensive than raw research powers, selling for over $500 per 1 milligram kit when purchased directly from an overseas pharmacy. This price will usually increase to nearly $700 when the kit is found on the U.S. black market. The higher price of the GenSci product is balanced by greater convenience and trust, as it is packaged in a similar “ready to use” manner as prescription Growth Hormone. In each box you will find 10 vials with 100 mcg hormone in each, and the necessary 10 ampules of sterile dilutent to mix them with. Once reconstituted, any unused portion should be refrigerated to preserve the stability of the protein.
Unlike HGH, which is given subcutaneously, IGF-1 Long R3 of is usually given as an intramuscular injection. Although SubQ injections are possible, they tend to involve a little more discomfort than regular IM injections. The bodybuilder will typically inject it into the muscle that they are training that day, in an effort to stimulate spot growth and a greater overall anabolic response. The dose given is usually in the range of 20-80 mcg, and given every day. The daily dosage can be further divided into two applications (spaced 10-12 hours apart) to allow for better stability in blood hormone levels. Some bodybuilders do venture above the 100 mcg daily mark, and some “top pros” are even rumored to take as much as 200 mcg per day during bulking cycles. With the astronomical costs that would be associated with such high-dosage use it is likely that these amounts are more the product of speculation than real common practice in the professional ranks. 30 mcg per day is probably the most commonly used dosage for the recreational bodybuilder, which allows a 1 mg vial to last for about a month. At $35 or so per day, this would seem to be a fairly reasonable investment in one’s physique by most accounts. $100 per day is a crack habit, and probably not warranted for most users.
Typical results from IGF-1 Long R3 of administration include intensified pumps, increased appetite, increases in lean muscle mass & strength, and the stimulation of thermogenesis (fat loss). A 30-day cycle usually imparts at least several pounds of new muscle tissue gain, and by most accounts its local spot-growth effect works very well. Some bodybuilders claim to have gained as much as 12-15 pounds off of a single week cycle of just IGF-1 Long R3. When taken alone, IGF-1 Long R3 is not quite as good as anabolic steroids for most of its users, but it is certainly not shabby for a non-steroidal anabolic either. By all accounts, muscle retention is also very high post-cycle, which usually can’t be said for steroids. This is due to a couple factors, including the lack of hormonal crash when he drug is discontinued.
When it comes to cutting, IGF-1 Long R3 is definitely not as potent as classic Human Growth Hormone. This is quite understandable, as we know that this is an activity that is inherent in the Human Growth Hormone molecule itself. Increased lipolyses is, likewise, not dependent on the stimulation of IGF-1 release the same way the anabolic attributes of GH are. That is not to say that IGF-1 is entirely without benefit. Users do still seem to comment that the drug has some noticeable effect as a fat loss agent. It seems to allow them to keep fat mass at bay, even when they are on a high-calorie (bulking) diet. Often they can even lose fat mass and tighten up their physiques while taking the drug during building phases of training, but individual metabolism seems to play a strong role in how noticeable this effect is. It is likely that a shift in the utilization of nutrients towards muscle growth, and not a direct lipolytic effect, is responsible for this, as IGF-1 is inherently more like Insulin (lipogenic) than GH in this regard. We can, therefore, say that IGF-1 is not going to be your number one drug choice for cutting up, but it may still make a good addition to any stack focused on lean muscle mass gains.
There are concerns that natural antibody reactions will start to work against the effectiveness of synthetic IGF-1 analogs like IGF-2 Long R3 of as the usage duration becomes prolonged. You will recall that this has been investigated with Somatrem, the synthetic 192 amino acid analog of Human Growth Hormone. For this reason, cycle length is usually limited to somewhere between 4 and 12 weeks. After this point a break of at least 4-6 weeks is usually taken, to ensure maximum responsiveness when drug therapy is again initiated. It is uncertain how crucial this is, however, at this time it seems like good advice given how little we currently know about the use of IGF-1 Long R3. But ensuring maximum effectiveness is not the only reason for limiting drug duration and dosage. There are other potentially serious side effects to IGF-1 therapy that need to be considered. These mimic the risks associated with GH therapy very closely, and include pronounced internal organ growth, thickening of the bones and skin (GH jaw), Insulin resistance, hypoglycemia, water retention and edema, and even gynecomastia in very sensitive users. Some people also report carpel tunnel syndrome from the overuse of GH or IGF-1, which may be preceded by numbness or discomfort in the hands and wrists. GH is known to be a strong drug, and IGF-1 is its powerful big brother in almost all regards. This agent should be respected, not abused. We must stress again that this is an unapproved new agent, and as such the full risks in humans have not yet been determined. You are in essence making a guinea pig out of yourself when taking it.
The fact that IGF-1 Long R3 is not yet an approved prescription drug in any country has definitely not stopped athletes from taking advantage of this agent. The potential benefit of this drug was simply too enticing to be ignored. As soon as the word was out about IGF-1 Long R3, the wheels started turning about how to get it onto the black market. Although not in abundant supply, enough channels for this drug have been established to ensure that a steady stream of athletes are able to use it. At least one drug manufacturing company has taken notice, and since started marketing it in a prepared form for human use. Several other companies are likely to follow suit in the next year or two. Many that have used IGF-1 Long R3 of are calling it “Super GH”, which in many regards is a fair perspective. IGF-1 drugs like this allow us the full anabolic benefit of this hormone, without being forced to rely on our own body’s ability to produce it in response to the administration of adhere difference can be likened to taking hCG to stimulate increased Testosterone levels, or injecting an actual drug form of the hormone like Testosterone Cypionate. We can see why IGF-1 Long R3 has earned the nickname “I Grow Faster” and become the cult drug of interest the past few years. Its popularity is only sure to grow as more athletes are given the opportunity to use it.