GH-RH

GH-RH (Sermorelin Acetate)

ALTERNATIVE STEROID NAMES: GH-RH, Sermorelin Acetate
ACTIVE SUBSTANCE: Sermorelin Acetate
Strength Gains: Strength gains 8/10
Mass & Weight Gains: Mass & Weight gains 8/10
Fat Burning: Fat burning 8/10
Cutting/Definition: Definition gains 10/10
Side Effects: Side effects 4/10
Ability to keep Gains: Ability to keep gains 10/10
Usual dosages: 0.5 – 1 mg per day
Detection time: As of 2009 not yet detectable.
Best combined with:
Bulking: Cytomel (T-3 thyroid), Testosterone Enanthate/Cypionate, Sustanon, Insulin.
Cutting: Cytomel (T-3 thyroid), Testosterone Enanthate/Cypionate, Sustanon, Insulin.
Beginner Use: Use for beginners 4/10
Female Use: Female use 5/10
Pros: Great bulking/mass/fat loss/cutting drug, Not detectable.
Cons: Expensive, Not yet tested, Hard to obtain.

SHORT GH-RH DESCRIPTION:

GH-RH or Sermorelin Acetate is a synthetically manufactured form of the endogenous growth hormone-releasing hormone. GH-RH increases the level of Growth Hormone in the blood by stimulating the pituitary gland to manufacture more of this hormone. Among other things, an elevated growth hormone level can elicit new muscle growth, increase fat loss, enhance energy levels and strengthen connective tissues. Sermorelin acetate does not remain active in the body for very long, so injections of this drug are to be given daily. Early reports suggest that 1 mg of GH-RH would have roughly the equivalent effect of 1 mg HGH (approximately 3 Ill’s).

LONG GH-RH DESCRIPTION:

GH-RH or Sermorelin Acetate comes usually from two different manufacturers, from Serono U.S. comes Geref and form Clinical U.S., which is named GH-RH. GH-RH or Growth Hormone Releasing Hormone, is an extremely new pharmaceutical compound that may be of future interest to the athlete/bodybuilder. GH-RH contains the active substance sermorelin acetate, which is a synthetically manufactured form of the endogenous growth hormone-releasing hormone (GHRH or GRF). The composition of sermorelin is actually just a portion of this polypeptide hormone, containing 29 of the 44 amino acids that make up its structure. It does however display the full activity of the parent, so the lack of entirety should not affect the potency of this drug. GH-RH, specifically the Geref brand name from Serono, was approved for sale in the U.S. in 1997 as a diagnostic tool to evaluate a possible pituitary deficiency. It is being further assessed as a substitute to injectable growth hormone in patients with an existing deficiency.

GH-RH increases the level of Growth Hormone in the blood by stimulating the pituitary gland to manufacture more of this hormone. This makes it a useful diagnostic tool, since a failed response to a Geref injection (no GH elevation) should indicate a problem with the pituitary gland (or related). The standard practice is to sample the blood growth hormone level, then administer a single intravenous injection of Geref. The blood GH level is then recorded every subsequent 15 minutes (4 samples taken during the first hour after the shot), and compared against the first reading. Many are confident this is just the beginning, and believe GH-RH will ultimately prove to be an efficient GH replacement drug. One can liken such a practice to the way HCG (human chorionic gonadotropin) is used to increase the production of testosterone in the body. Just as is the case with testosterone, the body is capable of producing much more GH than it typically does. It is quite possible that regular use can produce a level of elevation consistent with an HGH replacement regimen.

Athletes would of course be attracted to this drug for the same reasons they use HGH. Among other things, an elevated growth hormone level can elicit new muscle growth, increase fat loss, enhance energy levels and strengthen connective tissues. The thermogenic and anabolic properties of growth hormone are readily known among bodybuilders and competitive athletes, many of who rely heavily on this compound. If GH-RH is able to sustain a GH elevation great enough for a beneficial effect (it appears to be), then it may enjoy great popularity on the black market in the years to come. As with HGH, one should remember that the full anabolic effect would be achieved only with the addition of other compounds. Most importantly, the body will have a heightened requirement for thyroid hormones, insulin and androgens. It is typical to add a small dosage of Cytomel (T-3 thyroid) and a long acting injectable androgen like testosterone enanthate. In addition, many find the periodic use of insulin to be particularly beneficial for enhancing new muscle growth.

Sermorelin acetate does not remain active in the body for very long, so injections of this drug are to be given daily. The athlete will inject the solution intramuscularly or subcutaneously (never IV), in order to extend its release time. The exact dosage that would be needed by a healthy athlete is currently unclear however. Early reports suggest that 1 mg of GH-RH would have roughly the equivalent effect of 1 mg HGH (approximately 3 Ill’s). This of course seems like a very promising figure. With this level of efficiency, one would assume that a daily dosage of .5 to 1 mg would prove sufficient for performance enhancement. This drug is of course so new that a standard injection protocol has not yet been established with athletes. It may come to be that more or less GH-RH is actually needed in order to receive noteworthy results.

The physical appearance of GH-RH is very similar to Growth Hormone. It comes packaged in two separate ampules, one containing a lyophilized powder (the active constituent) and the other a sterile dilutant. Each ampule pair will typically contain 0.5 mg or 1 mg of sermorelin acetate, and will obviously need mixing before use. Just as with HGH, the patient must be very careful not to disturb the contents much during this process. As with HGH, the accompanying paperwork states that if a cloudy or discolored solution is produced, the drug should be discarded. Unlike HGH however, an unused potion of GH-RH cannot be refrigerated for later use. One obviously would not want to be stuck purchasing 1 mg vials if they only needed 0.5mg per day. This would not seem very important if GH-RH was cheap, but this is not the case. Overseas sources are currently showing the price of this drug to be comparable to HGH; at about $75 per a daily dosage of 1 mg. Perhaps we will see a reduction in price as the manufacture and use of this compound become more widespread.

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