SHORT GEREF DESCRIPTION:
Geref contains the active substance Sermorelin Acetate, which is a synthetically manufactured form of the endogenous Growth hormone-releasing peptide (GHRH or GRF). The standard practice is to sample the blood Growth Hormone level, then administer a single intravenous injection of Geref (l-2 mcg/kg). The blood GH level is then recorded at 15 minutes, 30 minutes, 60 minutes, and 120 minutes (4 samples are taken after the shot), and compared against the first reading to judge the level of response.
LONG GEREF DESCRIPTION:
Geref contains the active substance Sermorelin Acetate, which is a synthetically manufactured form of the endogenous Growth hormone-releasing peptide (GHRH or GRF). The composition of Sermorelin is actually just a portion of this polypeptide hormone, containing 29 of the 44 amino acids that make up its structure. It does however display the full activity of the parent, so one should not worry that the lack of entirety will effect the potency of this drug. Geref was approved for sale in the U.S. in 1997 as a diagnostic tool to evaluate a possible pituitary deficiency. It is being further assessed as a possible substitute to injectable Growth Hormone in patients with an existing deficiency, although one does wonder how far this avenue will be taken given the more recent approval of recombinant human IGF-1. In addition to the U.S. product, Serono has opened markets for Geref in a number of other countries.
GHRH increases the level of Growth Hormone in the blood by stimulating the pituitary gland to manufacture more of this hormone. This makes Geref a useful diagnostic tool, since a failed response to an injection (no GH elevation) should indicate a problem with the pituitary gland (or related). The standard practice is to sample the blood Growth Hormone level, then administer a single intravenous injection of Geref (l-2 mcg/kg). The blood GH level is then recorded at 15 minutes, 30 minutes, 60 minutes, and 120 minutes (4 samples are taken after the shot), and compared against the first reading to judge the level of response. Many are confident this is just the beginning, and believe GHRH may one day prove to be an efficient GH replacement drug. One can liken such a practice to the way hCG (Human Chorionic Gonadotropin) is used to increase the production of Testosterone in the body. Just as is the case with Testosterone, the body is capable of producing much more GH than it typically does. It is quite possible that regular use can produce a level of elevation consistent with an HGH replacement regimen.
Athletes would, of course, be attracted to this drug for the same reasons they use HGH. Among other things, an elevated Growth Hormone level can elicit new muscle growth, increase fat loss, enhance energy levels and strengthen connective tissues, The thermogenic and anabolic properties of Growth Hormone are readily known among bodybuilders and competitive athletes, many of who rely heavily on this compound. If GHRH is able to sustain a GH elevation great enough for a beneficial effect (it appears to be), then it may enjoy great popularity on the black market in the years to come. As with hormone should remember that the full anabolic effect would be achieved only with the addition of other compounds. Most importantly, the body will have a heightened requirement for Thyroid hormones, Insulin, and Androgens. It is typical to add a small dosage of Cytomel (T-3 Thyroid) and a long acting injectable Androgen like Testosterone Enanthate. In addition, many find the dally use of injectable Insulin to be particularly beneficial for enhancing new muscle growth potential.
Sermorelin Acetate does not remain active in the body for very long, so injections of this drug are to be given daily. The athlete will inject the solution intra muscularly or subcutaneously (never IV), in order to extend its release time. The exact dosage that would be needed is currently unclear, however. Early reports suggest that 1 mg of GHRH (subcutaneous injection) would have roughly the equivalent effect of 1 mg rHGH (approximately 3 IU’s). With such level of efficiency, one would assume that a daily dosage of .5 to 1 mg would prove sufficient for performance enhancement. This would equate to 10 ampules of Geref, however, which is quite a bit of drug to take (the powder can be mixed with less diluent so as to reduce volume). GHRH, of courses so new that a standard injection protocol has not yet been established with athletes. It may come to be that more or less is actually needed in order to receive noteworthy results (hopefully less).
The physical appearance of Sermorelin Acetate is very similar to Growth Hormone. It comes packaged in two separate ampules, one containing a lyophilized powder (the active constituent) and the other a sterile dilatant. Each ampule pair will provide 50 mcg of Sermorelin Acetate, and will obviously need mixing before use. Just as with HGH, the patient must be very careful not to disturb the contents much during this mixing process. The accompanying paperwork states that if a cloudy or discolored solution is produced, the drug should be discarded. Unlike HGH, however, an unused potion of Geref cannot be refrigerated for later use (it also must be shipped and stored under refrigeration). Given the low dosage of this preparation, storage of an unused portion is likely not going to be a problem. It may, however, turn out to be a problem if higher dosed versions of the drug surface. This would not be very important if Geref were cheap, but it isn’t (using Geref for performance enhancement would be far more costly than HGH). Perhaps we will see a reduction in price as the manufacture and use of this compound become more widespread. Until then, Geref is very promising, but also very impractical.