Aldactone (Spironolactone)

ALTERNATIVE STEROID NAMES: Spironolactone, Aldactone, Novo-Spiroton, Aldactazide, Spiractin, Spirotone, Verospiron, Berlactone.
ACTIVE SUBSTANCE: Spironolactone
Strength Gains: Strength gains 0/10
Mass & Weight Gains: Mass & Weight gains 0/10
Fat Burning: Fat burning 0/10
Cutting/Definition: Definition gains 5/10
Side Effects: Side effects 5/10
Ability to keep Gains: Ability to keep gains 0/10
Usual dosages: 25 – 100 mg per day
Detection time: NA
Best combined with:
Cutting: Lasix, Dyazide.
Beginner Use: Use for beginners 6/10
Female Use: Female use 8/10
Pros: Low side effects for a diuretic, easy to find.
Cons: Not as effective as Lasix.


Aldactone (Spironolactone) is a mild diuretic, manufactured widely throughout the world. Medically this class of drug is used to treat high blood pressure, efficiently lowering the retention of water and salt. Aldactone acts by reducing the amount of aldosterone secreted by the adrenal gland, which is the hormone primarily responsible for water regulation in the body. This effect is beneficial to competitive bodybuilders, who need to shed subcutaneous water before a showing. Specifically this compound is a potassium-sparing diuretic, much weaker in effect than both Dyazide and Lasix. As can be surmised, potassium levels are not greatly reduced with Aldactone. This is much unlike many stronger diuretics that can increase the rate of potassium excretion considerably. It is therefore very important that the user does not take any additional potassium supplement while using this compound. Too high an increase in potassium levels can prove to be life-threatening.

Using diuretics can present a number of unwanted side effects to the user. This includes, but is not limited to, dehydration, cramping, diarrhea, dizziness, headache, anxiety, unrest, weakness, numbing of extremities and cardiac irregularities. Such side effects seem much less common with this class of diuretic, but should still be of concern. Additionally, this compound exhibits notable anti-androgenic properties. This is because spironolactone is both a weak inhibitor of androgen/receptor binding, and a strong inhibitor of testosterone biosynthesis. Since athletes generally use Aldactone for a very short period of time, interference with androgen levels should not be much concern however.

Male competitors generally find a dosage of 100 mg per day, in a single Morning application, effective for subcutaneous water excretion. This is continued for 3 to 5 days prior to a showing and should result in a harder, more defined appearance to the muscles. Overuse of diuretics can result in notable dehydration, producing the unwanted look of “flattened” muscles. This is not a common occurrence with potassium-sparing diuretics, but is still possible. Many competitors in fact find Aldactone too mild, and require stronger drugs like Lasix and Hydrodiuril, also with increased risks. Women are occasionally attracted to this product for its effect as an anti-androgen. It can be used at a point when androgen levels have become problematic during a cycle, hopefully reducing the risk of virilization symptoms. A dosage of 25-75 mg daily for 1 to 2 weeks may be enough to ward off side effects while androgen levels decline (the steroid regimen terminated). Since spironolactone is more effective at lowering endogenous androgen levels than inhibiting androgen action, it is certainly not to be considered a cure-all remedy for the adventurous steroid-using female concern.

Since this compound is one of our safest (prescription) options, it is an obvious starting point for a beginning competitor. Once familiar with Aidactone and wishing for a stronger effect, the addition of a thiazide or furosemide (Lasix) can prove successful. Here the overall dosage is to be reduced than if using either substance alone, and should provide strong water excretion with less calcium/potassium loss.

If mixing with hydrochlorthiazide, we can cut the Aidactone dosage in half (from 100 mg) and add an equal mg amount of the thiazide. The 50 mg/50 mg combination should noticeably increase water excretion without dramatic side effects. The potassium re-absorption seen with Aidactone should be balanced out with the thiazide, so potassium levels should not be greatly affected. On the other hand, Lasix (furosemide) makes a much stronger addition to Aidactone. In this case, dropping the Aidactone dosage to 50 mg and addition 20 mg oral Lasix is a popular place to start, hopefully providing the water-shedding effect of a 40 mg Lasix tablet. Again, the potassium depleting effect of Lasix will likely be balanced out by the Aidactone, so no additional supplement should be needed. In Europe many such combination diuretics are available and appear to be well liked among competitors.

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