Anadrol 50

Anadrol 50 (Oxymetholone)

ALTERNATIVE STEROID NAMES: Anadrol, Anadrol-50, Anapolone oxymetholone, Oxymetholon, Dynasten, Roboral, Synasteron, Hemogenin, Oxitosona, Oxanabolic, Oxy 50
Strength Gains: Strength Gain 10/10
Mass & Weight Gains: Mass & Weight Gain 10/10
Fat Burning: Fat Burning 0/10
Cutting/Definition: Fat Burning 0/10
Side Effects: Side Effects 9/10
Ability to keep Gains: Ability to keep Gains: 1/10
Usual dosages: 50 – 150 mg per day
Detection time: 2 Months
Best combined with:
Bulking: Deca Durabolin, Primobolan, Winstrol, Sustanon (generally all testosterones)
Cutting: Anadrol is usually not used in cutting cycles
Beginner Use: Use for Beginners 2/10
Female Use: Female Use 0/10
Pros: Extremely rapid strength and mass buildup, easily obtainable.
Cons: Very strong side effects, Most of the gains are lost after the cycle.


Anadrol 50 is the strongest and at the same time also the most effective oral steroid. It is a 17alpha alkylated oral steroid. It will produce extremely dramatic weight and strength gains in its user. A dosage sufficient for any athlete would be 0,5 – 0,8 mg per pound of body weight per day.

Some of this weight and strength gain will be due to the drugs heavy water retention. Users report severe crashes when stopping usage, mostly due to the loss of water and inhibited endogenous hormone production brought about during the cycle. Aside from the water, it will pack on the mass like no other steroid. A short cycle of Anadrol could account for a gain of over 20lbs in many users, sometimes more. As this drugs anabolic properties are so extreme, so are it’s androgenic side effects. Due to the strength of these side effects, should never be used by women. For starters, Oxymetholone will easily convert to estrogen and DHT. As stated earlier water retention will be present, along with an increase in blood pressure. Kidney functions may also need to be looked after during longer use. The most dangerous attribute is that is it 17alpha alkylated. As you probably know 17aa orals are toxic to the liver, so it is pertinent a user has his liver enzymes checked regularly with a doctor.


Anadrol 50 is the U.5. brand name for Oxymetholone, a very potent oral androgen. This compound was first made available in 1960, by the international drug firm Syntex. Since Oxymetholone is quite reliable in its ability to increase red blood cell production (and effect admittedly characteristic of nearly all anabolic/androgenic steroids), it showed particular promise in treating cases of severe anemia. For this purpose it turned out to be well suited, and was popular for quite some time. But recent years have brought fourth a number of new treatments, most notably the non-steroidal hormone Epogen (Erythropoietin). This item is shown to have a much more direct effect on the red blood cell count, without the side effects of a strong androgen. Financial disinterest finally prompted Syntex to halt production of the U.S. Anadrol 50 in 1993, which was around the same time they decided to drop this item in a number of foreign countries. Plenastril from Switzerland and Austria was dropped; following soon was Oxitosona from Spain. Many Athletes feared Anadrol might be on the way out for goodbye new HIV/AIDS studies have shown a new light on Oxymetholone. These studies are finding exceptional anti-wasting properties to the compound and believe it can be used safely in many such cases. Interest has been peaked, and as of 1998 Anadrol is again being sold in the United States. This time we see the same Anadrol brand name, but the manufacturer is the drug firm Unimed. Syntex continues to market & license this drug in a number of countries, however (under a few different brand names).

Anadrol is considered by many to be the most powerful steroid commercially available, with results of this compound being extremely dramatic. A steroid novice experimenting with Oxymetholone is likely to gain 20 to 30 pounds of massive bulk, and it can often be accomplished in less than 6 weeks, with only one or two tablets per day. This steroid produces a lot of trouble with water retention, so let there be little doubt that much of this gain is simply bloat. But for the user this is often little consequence, feeling bigger and stronger on Anadrol than any steroid they are likely to cross. Although the smooth look that results from water retention is often not attractive, it can aid quite a bit to the level of size and strength gained. The muscle is fuller, will contract better and is provided a level of protection in the form of “lubrication” to the joints as some of this extra water is held into and around connective tissues. This will allow for more elasticity, and will hopefully decrease the chance for injury when lifting heavily. IT should be noted however, that on the other hand the very rapid gain in mass might place too much stress on your connective tissues for this to compensate. The tearing of pectoral and biceps tissue is commonly associated with heavy lifting while massing up on steroids. There can be such a thing as gaining too fast. Pronounced estrogen trouble also puts the user at risk for developing gynecomastia. Individuals sensitive to the effects of estrogen, or looking to retain a more quality look, will therefore often add Nolvadex to each cycle.

It is important to note, however, that this drug does not directly convert to estrogen in the body. Oxymetholone is a derivative of Dihydrotestosterone, which gives it a structure that cannot be dramatized. As such, many have speculated as to what makes this hormone so troublesome in terms of estrogenic side effects. Some have suggested that it has presentational activity, similar to Nandrolone, and is not actually estrogenic at all. Since the obvious side effects of both estrogens and protesting are very similar, this explanation might be a plausible one. However we do find medical studies looking at this possibility. One such tested the presentational activity of various steroids including; Nandrolone, Norethandrolone, Methandrostenolone, Testosterone and Oxymetholone. It reported no significant presentational effect inherent in Oxymetholone or Methandrostenolone, slight activity with Testosterone and strong presentational effect inherent in Nandrolone and Norethandrolone. With such findings it starts to seem much more likely that Oxymetholone can intrinsically activate the estrogen receptor itself, similar to but more profoundly than the estrogenic androgen Methandriol. This means that we can only combat the estrogenic side effects of Oxymetholone with estrogen receptor antagonists such as Nolvadex or Clomid, and not with an aromatize inhibitor. The strong antiaromatase compounds such as Cytadren and Arimidex would similarly prove to be totally useless with this steroid, as aromatize is not involved.

Anadrol is also a very potent androgen, and tends to produce many pronounced, unwanted androgenic side effects. Oily skin, acne, and body/facial hair growth can be seen very quickly with this drug. Many individuals respond with severe acne, often requiring medication to keep it under control. Some of these individuals find that Accutane works well, which is a strong prescription drug that acts on the sebaceous glands to reduce the release of oils. Those with a predisposition for male pattern baldness may want to stay away from Anadrol completely, as this is certainly a possible side effect during therapy. And while some very adventurous female athletes do experiment with this compound, it is much too androgenic to recommend. Irreversible virilization symptoms may be the result and occur very quickly, possibly before you have a chance to take action.

It is interesting to note that Anadrol does exhibit some tendency to convert to Dihydrotestosterone, although this does not occur via the 5-alpha reductive enzyme (responsible for altering Testosterone to form DHT) as it is already a Dihydrotestosterone based steroid. Aside from the added c-17 alpha alkylation, Oxymetholone differs from DHT only by the addition of a 2-hydroxymethylene group. However, this grouping clearly supports this notion be removed metabolically, reducing Oxymetholone to the potent androgen 17alpha-methyl dihydrotestosterone (Mestanolone; methyldihydrotestosterone). There is little doubt that this biotransformation contributes at least on some level to the androgenic nature of this steroid, especially when we note that in its initial state Anadrol has a notably low binding affinity for the androgen receptor. So although we have the option of using the reductive inhibitor Finasteride (Proscar) to reduce the androgenic nature of Testosterone, it offers us no benefit with Anadrol as this enzyme is not involved.

The principle drawback to Anadrol is that it is a 17-alpha alkylated compound. Although this design gives it the ability to withstand oral administration, it can be very stressful to the liver. Anadrol is sometimes suspected of being particularly dubious because it requires such a high milligram amount per dosage. The difference is great when comparing it to other oral steroids like Dianabol or Winstrol which have the same c-l7alpha alkylation. They have a slightly higher affinity for the androgen receptor, and are effective in much smaller doses (seen in the 5 mg and 2 mg tablet strengths). Anadrol has a lower affinity, which helps explain why we have a 50 mg tablet dosage. When looking at the medical requirements, the recommended dosage is very high, landing between 1 mg and 2 mg per kilogram of body weight. This would give a 220 lb person a dosage as high as 10 Anadrol tablets (500 mg) per day. There should be little wonder why when liver cancer has been linked to steroid use, Anadrol is generally the culprit, and high medical doses generally the setting. Athletes actually never need such a high dosage, and will generally take in the range of 1-3 tablets per day. Many happily find that one tablet is all they need for exceptional results, and avoid higher amounts. Cautious users will also limit the intake of this compound to no longer than 4-6 weeks, and have their liver enzymes checked regularly with a doctor. Kidney functions may also need to be looked after during longer use, as water retention/high blood pressure can take a toll on the body. Before starting a cycle, one should know to give Anadrol the respect it is due. It is a very powerful drug, and not always a friendly one.

When discontinuing Anadrol, the crash can be as equally powerful as the on-cycle results. To begin with, the level of water retention will quickly diminish, dropping the user’s body weight dramatically. This should be expected, and not of much concern. What is of great concern is restoring endogenous Testosterone production. Anadrol will quickly and effectively lower natural levels during a cycle, so hCG and/or Clomid/Nolvadex are a must when discontinuing a cycle. The common practice of slowly tapering off your pill dosage is wholly ineffective at raising Testosterone levels. Without ancillary drugs, hormonal imbalance will likely strip a good amount of the muscle that was gained during the cycle. If hCG and/or Clomid/Nolvadex are used properly, the person should e able to maintain much more of it. Before going off, some alternately choose to first switch over to a milder indictable like Deca-Durabolin. This is in an effort to harden up the new mass and can prove to be an effective practice. Although a drop of weight is likely when making the switch the end result should be the retention of more (quality) muscle mass with a less pronounced crash (in a sort of stepping down, first off the water bloat, and next off the hormones). Remember ancillaries though, as Testosterone production will not be rebounding during Deca-Durabolin therapy.

Oxymetholone remains widely available on the black market. Although there are many counterfeits in circulation, there are also enough legitimate companies making the drug to make some good suggestions when shopping.

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