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As we all know, Testosterone was the first steroid to be synthesized, and now it remains the gold standard of all steroids. First, we will discuss Testosterone in general, and in depth, then well examine exactly how and what the propionate ester is (together, Testosterone Propionate is often referred to as just “prop” test-p or “test prop”).
Testosterones anabolic/androgenic ratio is 1:1 meaning it is exactly as anabolic as it is androgenic. Actually, testosterone is the steroid that all anabolic/androgenic ratios are based on. If a steroid is 2:1, then it is, compared with testosterones ratio, doubly as anabolic as it is androgenic. Hence, we see from testosterones ratio, it is both quite anabolic as well as androgenic. It should be noted; as Testosterone Propionate is merely testosterone, this anabolic/androgenic rating holds the same.
So how exactly does Testosterone Propionate build muscle? Testosterone Propionate promotes nitrogen retention in the muscle (6), and the more nitrogen the muscles hold the more protein the muscles store, and the bigger the muscles get. Testosterone Propionate can also increase the levels of another anabolic hormone, IGF-1, in muscle tissue (7). IGF-1 is alone highly anabolic and can promote muscle growth. It is responsible for much of the anabolic activity of Growth Hormone (GH). IGF-1 is also one of the few hormones positively correlated with both muscle cell hyperplasia and hyperphasia (this means it both creates more muscle fibers as well as bigger fibers). All of this might lead one to speculate that for pure mass, IGF-1, HGH, and Testosterone Propionate would be a very effective combination. Testosterone Propionate also has the amazing ability to increase the activity of satellite cells(8). These cells play a very active role in repairing damaged muscle. Testosterone also binds to the androgen receptor (A.R.) to promote all of the A.R dependent mechanisms for muscle gain and fat loss (9), but clearly, as we’ve seen, this isnt the only mechanism by which it promotes growth.
Testosterone Propionate has a profound ability to protect your hard earned muscle from the catabolic (muscle wasting) glucocorticoid hormones (11), and increase red blood cell production (12), and as you may know, a higher RBC count will improve endurance via better oxygenated blood. The former trait increases nitrogen retention and muscle building while the latter can improve recovery from strenuous physical activity, as well as increase endurance and tolerance to strenuous exercise.
Testosterone occurs naturally in both the male and female body, as insofar as drug testing for it, typical tests dont work (i.e. testing for metabolites). Testosterone can be tested for on a testosterone/epitestosterone ratio, a failing result usually being anything over 6 to 1, but there are other more effective tests currently in use as well as being developed by the usual party-poopers in the IOC and FDA. Noteworthy is that if you are using low doses of Testosterone Propionate and stop taking it 36-48 hours before a testosterone/epitestosterone analysis, you can still pass!
Testosterone Treatment only $199/month All-Included Testosterone, once in the body can be converted to both estrogen (via a process known as aromatization) as well as dihydrotestosterone (DHT). Estrogen is the main culprit for many side effects such as gynecomastia, water retention, and as a result high blood pressure while DHT is often blamed for hair loss and prostate enlargement. Naturally there are ways to combat this, such as using an anti-estrogenic compound along with your Testosterone Propionate, or even an estrogen blocker. DHT can be combated (on the scalp, to prevent hair loss) with compounds such as Ketoconazole shampoo (sold under the trade name Nizoral) as well as Finasteride (sold as Proscar in the 5mg version and as Propecia as 1mg tablets). Interestingly, this shampoo can also be used topically to combat acne on the face (or even the back if youre really flexible). Both of these methods for preventing hair loss and acne are reasonably effective; however, if you are not predisposed to male pattern baldness they will be wholly unnecessary. Male Pattern Baldness (MPB) is carried by the X chromosome, so if your mothers family boasts men with full heads of hair, then you are probably safe (unless those full heads of hair are all mullets). Naturally, as with most other steroids, your lipid profile is going to suffer a bit while supplementing with Testosterone Propionate. This, of course is nothing that cant be controlled by watching your diet and doing your cardio, at least for the duration of the typical cycle (which for arguments sake, Ill assume is +/- 12-16weeks). Lets be totally honest, here, even a modest amount of exercise will improve your blood pressure and lipid profile (10).
In-order to combat the aromatization of testosterone, you can simply take an aromatase inhibitor such as Arimidex. This and other anti-estrogenic compounds are generally considered a must with testosterone doses over a gram per week (1,000mgs), and often recommended with even less. Also among side effects (as if acne and going bald arent enough) is increased aggression. This is a hotly debated issue in steroid-culture. Generally the consensus is that if you are prone to being a jerk, you’ll be a bigger jerk, and if you aren’t, then your temper will not get much worse (this is supported by research as well.) Interestingly enough, high levels of testosterone are generally only associated with improper aggression and anti-social behavior in males with lower intelligence (1)(2).
Guess what? Dumb people shouldn’t use steroids at all, especially testosterone!
For many, the increased aggression found from increased testosterone levels is often a bonus in the weight room as well as on the playing field. Lets not get started on its benefits in the bedroom!
Testosterone Propionate is also a relatively safe steroid to use, with some studies showing no adverse effects from 20weeks at 600mgs/week! (3)
Testosterone is usually attached to an ester (i.e. when you buy Testosterone Propionate, the subject of this profile, you are buying testosterone with a Propionate ester attached). The ester determines how long it takes your body to dispose of the steroid in question, and Propionate is the shortest ester available with a testosterone base (of course, Testosterone Suspension has no ester). There are enzymes, called esterases, in your body that have the function of removing the ester from steroids, and leaving you with just the steroid molecule with the ester cleaved off. Depending on how heavy the ester chain is, that determines how long it takes the esterase to remove it, and that amount of time determines how long the steroid stays active in your body. Great, right? No, not t really; the ester takes up space in the injection.
Check out this chart:
Chemical = Formula = Molecular Weight = Mg of Testosterone
Testosterone (no ester) = C19 H28 O2 = 288.4mg = 100mg
Propionate = C3 H4 O = 56.1mg = 83.72mg
Cypionate = C8 H4 O = 124.2mg = 69.90mg
Here, were comparing Testosterone with no ester (suspension) with Testosterone Propionate and Testosterone Cypionate (basically the longest vs. shortest esters available with testosterone).
So you see, the longer the ester on the testosterone hormone is, the longer the steroid is active in your body, and the less actual testosterone you get. This is because, for every 100mgs of Testosterone Cypionate you inject, only 69.90mgs of it is actually testosterone, the rest is the Cypionate ester, which must be removed. On the other hand, with the Propionate ester youll get 83.72mgs of testosterone! The advantage to longer esters is that they need to be injected less frequently (Testosterone Propionate needs to be injected every other day while you can shoot Testosterone Cypionate once per week). The disadvantage to long estered steroids is that they contain less actual steroid. Anecdotally, however, most people from Steroid.com and other discussion boards who have tried differing esters on their various cycles agree: Testosterone Propionate causes the least side effects and the least bloating. For this reason, its often the testosterone of choice in cutting cycles.
Testosterone levels when youre using injectable Testosterone Propionate begin to decline sharply after the second day of use(5). Obviously this is not the steroid of choice for those who are squeamish about injections, youll be shooting this stuff every other day at least.
Also, as with most steroids, injected testosterone will inhibit your natural testosterone levels and HPTA (Hypothalamic Pituitary Testicular Axis). A mere 100 mgs of Testosterone Propionate per week takes about 5-6 weeks to shut down the HPTA, and 250-500mgs shuts you down by week 2 (4).
Realistically, every cycle should contain testosterone. Go back and read that sentence again. A beginners dose of testosterone (i.e. someone on their first or second cycle of AAS) would be in the 250-500mgs ranges. Though, realistically, we wouldnt recommend much less than 400mgs of testosterone per cycle for anybody, beginner or not who is supplementing for the purpose of performance, and guess what? The more you use the more results you get, and frequently, the more side effects too (3).
Testosterone Propionate Stack
What stacks well with Testosterone Propionate? Everything! Many peoples favorites are Equipoise (Boldenone Undeclyenate) or Deca Durabolin (Nandrolone Decanoate), but really, anything will stack well with Testosterone Propionate. Trenbolone (Trenbolone Acetate), Masteron (Drostanolone), and Winstrol (Stanozolol) are also favorites for many on a cutting cycle. Its important to remember that since Testosterone Propionate has such a short ester, most people stack it with other short estered drugs, the rational being that they need to endure frequent injections for the Testosterone Propionate to be effective, so they may as well be using other drugs requiring the same dosing protocol.
Finally, its worth noting that sometimes a strategy known as “frontloading” is employed with Testosterone Propionate, this is where double or triple the intended dose for the cycle is injected for the first two weeks, then the user switches to a longer ester. The reasoning behind this is presumably to get the blood levels of the hormone up quickly in the hopes of seeing results more rapidly.
Buy Testosterone Propionate
Of all testosterones available on the market today, Testosterone Propionate is the most expensive. This is both because it is in high demand (due to its ability to avoid bloating the user as other testosterones tend to do) and because the actual chemical is expensive compared to other testosterones. Expect to pay roughly $40-60 for a 10-20ml bottle dosed at 100mgs/ml, when buying from a reputable Underground Lab, expect to pay double (or more than) that amount if you are buying Human grade ampules or bottles from a major pharmaceutical company.
Facts About Testosterone-Propionate
Testosterone-Propionate is a short ester based anabolic steroid of the testosterone family and is one of the oldest forms available since the inception of synthetic anabolic steroids. As a short ester based testosterone Testosterone-Propionate is very easy to control in-terms of maintaining stable blood levels; an important factor in testosterone administration and therapy; however, in order to achieve this end frequent injections of the medication will prove to be of an absolute necessity. Nevertheless, those who supplement with Test-Prop as it is commonly known will find all the benefits of testosterone supplementation to be achievable via this particular form.
Testosterone-Propionate is simply testosterone; compared to other forms there is no difference in-terms of mode of action as the nature of the testosterone hormone is the same in each form in-terms of benefits and function. Like all testosterone forms, Testosterone-Propionate is defined by the ester that is attached, as is the case with all forms or in some cases defined by the lack of ester attached, as can be the case in certain instances. To fully understand the compound we need only understand two things; the active hormone itself and then the ester and how it affects its mode of action in-terms of time release and active duration.
Testosterone-Propionate is a highly anabolic and androgenic hormone, equal in both parts. As a testosterone based hormone it is generally well-tolerated by all who supplement with it as testosterone is naturally produced in the body and is not a foreign hormone to natural human function. Not only is testosterone naturally produced by all human beings it is essential for proper endocrine function; those who suffer from low levels of testosterone will find they suffer from a host of issues from decreases in strength and muscle tissue, decreased libido, insufficient immune system function, depression, lack of mental clarity and increases in body-fat to name a few. Conversely, those who exceed their natural testosterone levels will find each category diminished when levels are low enhanced when levels are of a higher nature.
While all testosterone forms can provide the same benefits, Testosterone-Propionate functions based on the ester attached; in this case the Propionate ester. A very short ester, as such milligram for milligram Testosterone-Propionate is more powerful than many other common forms. For example, another common form of testosterone is that of Testosterone-Cypionate; 100mg of Testosterone-Cypionate will yield approximately 70mg of active testosterone; however, as the Propionate ester takes up less mass in the compound 100mg of Testosterone-Propionate will yield approximately 83mg of testosterone.
As a short ester based testosterone Testosterone-Propionate carries a half-life of approximately 4 days; the shortest half-life of all common ester based testosterones. As such, once administered the active hormone enters the blood stream and becomes active in full capacity very quickly but it also dissipates just as fast. For example, 100mg of Testosterone-Propionate administered on day one will fall to 50mg by day 4 and 25mg by day 8 and so on. Conversely, so that you may understand the significance, 100mg of Testosterone-Cypionate administered on day one will fall to 50mg but not until day 12 post injection. For this reason, in order to maintain stable and peak levels of the hormone in the body we must necessarily administer the hormone once every 3 days with every other day being optimal.
Benefits of Using Testosterone Propionate
As a testosterone based anabolic steroid the benefits of Testosterone-Propionate supplementation are nothing short of amazing and truly encompass almost every benefit one who uses anabolic steroids would desire. As a testosterone such benefits will include but are not limited to:
Increased Muscle Mass
Increased Levels of IGF-1
Increased Sex Drive
A Greater Sense of Well-Being
Greater Athletic Performance
As you can easily see the benefits are truly great and largely understood by a simple brief overview of testosterone. Testosterone greatly increases nitrogen retention thereby allowing more protein to be stored in the muscles of the body thereby increasing protein synthesis. Further, as by its nature, testosterone greatly blocks and reduces the glucocorticoid hormones in the body; the muscle wasting hormones that not only destroy muscle tissue but promote body-fat gains as well. Equally as important, as powerfully anabolic and androgenic testosterone promotes recovery and regeneration; the faster we recover the faster and greater our growth; further, the greater our regeneration the greater our athletic performance. When you couple this with its ability to increase the potent naturally occurring anabolic hormone IGF 1 you truly have a remarkable anabolic steroid in Testosterone-Propionate.
Side-Effects of Testosterone Propionate
All anabolic steroids carry with them possible negative and adverse side-effects; in that Testosterone-Propionate makes no exception. However, often the effects are highly exaggerated and it is important to note that through responsible use in healthy adult men such side-effects can largely be controlled and often of little concern at all. The most common side-effects of Testosterone-Propionate use will be estrogenic related due to the aromatase process. As testosterone will convert to estrogen via the aromatase enzyme common side-effects include but are not limited to:
High Blood Pressure
These are the most common side-effects but all hope is not lost. We can greatly reduce these side-effects by taking two precautions; ensuring our diets are full of healthy omega fatty acids and through the use of quality aromatase inhibitors such as Arimidex or Letrozole. However, there is one side-effect that will occur in all men who supplement with Testosterone-Propionate and that is testicular atrophy. Exogenous testosterone use will suppress your natural production; however, once use is discontinued normal production will begin again and testicular size will return to normal.
Human Growth Hormone is produced in the body by the pituitary gland. Before this happens, Growth Hormone Releasing Hormone (Human Growth Hormone RH) and Somatostatin (SST) are released by the hypothalamus, and that determines whether more or less Human Growth Hormone is produced by the pituitary.(1) Many factors influence the release of Human Growth Hormone, however, including nutrition and exercise (6)(7).
Once it is released, Human Growth Hormone (Human Growth Hormone), which is also called Human Growth Hormone (STH) has many functions in the human body. Human Growth Hormone is a protein that stimulates the body cells to increase both in size, as well as undergo more rapid cell division than usual. In addition, it enhances the movement of amino acids through cell membranes and also increases the rate at which these cells convert these molecules into proteins. Clearly, you can see that this would amount to an anabolic (muscle building) effect in the human body. Human Growth Hormone also has the ability to cause cells to decrease the normal rate at which they utilize carbohydrates, and simultaneously increase the rate at which they use fats.(1) Fat loss and lean mass increases with Human Growth Hormone have been found at a dose as low as . 0.028 iu/kg/daily for 24 weeks (4), however, in my estimation, that would be insufficient for a bodybuilder trying to gain muscle. Lets use .028iu/kg as a working number; that’s 2.8iu for a 100kg (220lbs) bodybuilder. That’s certainly not unreasonable, and I would say that that dose to 2x that dose is the range most bodybuilders and athletes are finding their best results with. Also, that length of time used in the study I just mentioned (24 weeks) is very typical of Human Growth Hormone use, and in conversations with my friends who have used this compound, have told me that they experience consistent results starting well after the 2-month-mark, and they tend to either run this stuff for 6 months at a time, or year-round (if they have sufficient funds). One of my friends is able to consistently retain a shredded 6-7% body fat all year round with the assistance of Human Growth Hormone, whether he is on steroids or off. He also has noted that his cardio (fast walking, for an hour a day) was much easier while on Human Growth Hormone than when off, and certainly the research Ive done would support his claim that sub maximal aerobic ability is improved with Human Growth Hormone use (5) (15).
How anabolic is this stuff? Well, even endurance athletes at rest (!) were observed in one study to be in an anabolic state (8). Yeah, so you can basically run marathons and take this stuff, and still build some muscle. Pretty impressive, right?
Human Growth Hormone is usually secreted in rhythmic pulses while you are sleeping, as two peptides, Human Growth Hormone RH and Somatostatin (SST) are alternately released. As you can guess, Human Growth Hormone RH (Growth Hormone Releasing Hormone) is the one responsible for the Release of Growth Hormone (And who said scientists have funny ways for naming things.(1)
Human Growth Hormone also has the ability to stimulate the production (or reproduction, in the case of an injury) of cartilage. This, however, requires the presence of a mediator substance, Somatomedin (IGF), which is released from the liver in response to Human Growth Hormone, and the IGF, in turn, actually promotes the growth of cartilage.(1)
Although Human Growth Hormone requires IGF to actually grow new cartilage, Human Growth Hormone is directly able to stimulate the elongation of bone tissue.(1), and Human Growth Hormone has also been shown to elicit a positive effects on erythropoeisis (9), which is great for both anabolism as well as endurance.
Remember the negative feedback loop I always tell you about? Well, of course, your body has one which can stop the secretion of Human Growth Hormone, and it involves IGF. When your liver receives secretes IGF-1, it sends a message to both your Hypothalamus as well as your Pituitary to stop producing Human Growth Hormone. (1)
As you have probably guessed by now, your body produces the majority of its Human Growth Hormone during your early years, when you are experiencing growth spurts. As you get older, however, you just produce less of this stuff, and its effects are much less pronounced. This was the driving force behind the (always weird) life-extension crowd embracing Human Growth Hormone in the early 90s. And, as usual, the driving force behind the athletic world embracing Human Growth Hormone was Dan Duchaine, which Im sure comes as no surprise to many. He first wrote a teaser about it in his Underground Steroid Handbook, and then wrote extensively about it for the next couple of decades. At that time, Grorm, was being used. This nasty stuff was Human Growth Hormone extracted from (are you ready?): the pituitary of dead bodies? Thats real “Dawn of the Dead” style science, in my opinion. I guess its an advance from a couple of centuries ago, when Descartes (the “I think therefore I am” guy) declared the pituitary the part of the human body where the soul resides. Anyway, back to the cadaver-thing, the Human Growth Hormone extracted from the cadavers was found to be able to (in rare cases) carry a rare brain disease. This of course, infected the kids who received the infected Human Growth Hormone. The use of Human Growth Hormone from cadavers was subsequently discontinued. Back then (the 80s) there was also a fake version of some purple looking Human Growth Hormone going around (it was HCG I believe, mixed with B-12) called “Rhesus Monkey Growth Hormone”, which is pretty funny, looking back on it. To this day, however, if you get fake Human Growth Hormone, its still probably HCG, since both come presented as a powder and bacterioistatic water you need to use to reconstitute it (and then it needs to be refrigerated).
Even if you are using the non-cadaver-derived stuff (and at this point, Im 100% sure that theres none of the old Grorm left on shelves anywhere), its possible that you experience some side effects like carpal tunnel syndrome, acromegaly (a thickening or growth of bones, most noticeable in the feet, hands, and forehead), and enlarged organs. Gynocomastia is also possible as a side effect of Human Growth Hormone use, as well as Fluid retention (16) (the later being initially pointed out to me by a female colleague who had a pre-contest bodybuilder using Human Growth Hormone as part of his contest prep).
Although Human Growth Hormone can easily produce very nice, high quality weight and muscle gains, its a very poor compound for inducing strength gains(2)(3)(4). Thats very counterintuitive, and certainly many strength athletes have experienced great results in strength as well as muscle size and fat loss from Human Growth Hormone. Generally, many studies have focused on Human Growth Hormone vs. Human Growth Hormone and exercise, and without the exercise LBM increases but not usually maximum voluntary strength output. It should also be noted that most athletes utilizing Human Growth Hormone are using it in a “cocktail” with (at least) anabolic steroids, and usually with IGF, thyroid meds, and other goodies such as an Aromatase Inhibitor.
Lets discuss exactly why this is.
Most people who are taking the plunge into Human Growth Hormone use have reached a dead end with their use of anabolics, and need to push through that wall. I’m sure you’ve heard about the synergistic combination of using Human Growth Hormone along with Anabolic Steroids, IGF, insulin and T3 (* usually synthroid, a thyroid medication). The reason is that when these hormones are used correctly together, theyll produce a large amount of synergy, the insulin is able to shuttle nutrients into your muscle, the thyroid hormone increases your fat-burning capability, the IGF will cause muscle growth as well as helping to grow new cartilage (thus preventing injury), and the anabolic steroids like testosterone, specifically (in addition to being anabolic) can increase IGF-1, in muscle tissue(11), and maybe even increase your bodys ability to use it. Also, usually, an increased amount of IGF usually tells your body to stop producing Human Growth Hormone, but testosterone actually blunts this part of the Negative FeedBack Loop (12)! And the addition of an Aromatase Inhibitor will also stop conversion of testosterone into estrogen; estrogen reduces IGF levels.(13)(14) Finally, the Human Growth Hormone does, well everything I just spent the last few pages telling you about!
Thus, IGF, Testosterone (and of course other steroids), Insulin, thyroid meds, and Human Growth Hormone will all combine to produce a pretty damned effective fat-burning and muscle building cycle! You know what else? Human Growth Hormone is virtually undetectable on any sort of currently used drug-screening tests. Human Growth Hormone, Insulin, Thyroid meds, and IGF may also be used pretty safely by those who may be subject to drug screening tests, or as a non-HPTA suppressive “bridge” between cycles.
Finally, Ill tell you how Id take Human Growth Hormone, personally. There was a study done on continuous Human Growth Hormone use vs. every other day injections (ED vs. EOD for the sake of brevity), with a equal total weekly dose. Although its counter intuitive, every other day injections produced better total growth in the kids in this (2 and 4 year long) study. Take a look at these graphs:
Growth velocity of children treated with alternate day Human Growth Hormone (the darker bars) or with a daily Human Growth Hormone regimen before, during, and 2 yr after stopping therapy. Values are the mean SD. *, P < 0.05; **, P < 0.01.(10)
Pretreatment and cumulative 4-yr growth velocity of children treated with alternate day Human Growth Hormone ( the darker bars) or with a daily Human Growth Hormone regimen. Values are the mean SD. *, P < 0.00 (10)
Shooting Human Growth Hormone every other day more accurately replicates the pulsile frequency of Human Growth Hormone, and thus gave better results for growth (height) deficient children, Human Growth Hormone pulsatility is necessary for proper function of the Human Growth Hormone receptor.(10) Dosing in the EOD nature reduces incidence of any sort of withdrawal problems associated with normal Human Growth Hormone use, including regression or retardation of growth after cessation of therapy.
Therefore, I feel very comfortable speculating that the use of Human Growth Hormone in this manner, which more closely simulates the natural secretion pattern of it, allows the Human Growth Hormone receptors and the rest of the body to more efficiently recover from it, and this will result in much more muscle growth over time (although height was examined in the previous study). My recommendations therefore are 2 shots per day of .028iu/kg of body weight, taken every other day, for a minimum of 3months, and preferably for 2-3x that long, and preferably with the other synergistic compounds we’ve just taken a look at.